About the Authors

Ernest J. Mui

Affiliation Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America

Guy A. Schiehser

Affiliation Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America

Wilbur K. Milhous

Affiliation Walter Reed Army Institute for Research, Silver Spring, Maryland, United States of America

Honghue Hsu

Affiliation Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America

Craig W. Roberts

Affiliation Department of Immunology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Scotland, United Kingdom

Michael Kirisits

Affiliation Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America

Stephen Muench

Affiliation Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, England, United Kingdom

David Rice

Affiliation Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, England, United Kingdom

J. P. Dubey

Affiliation United States Department of Agriculture, Agricultural Research Services, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland, United States of America

Joseph W. Fowble

Affiliation Department of Chemistry, University of Washington, Seattle, Washington, United States of America

Pradipsinh K. Rathod

Affiliation Department of Chemistry, University of Washington, Seattle, Washington, United States of America

Sherry F. Queener

Affiliation Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

Susan R. Liu

Affiliation Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America

David P. Jacobus

Affiliation Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America

Rima McLeod

rmcleod@midway.uchicago.edu

Affiliations Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America, Department of Pediatrics, Committee on Molecular Medicines, Genetics, and Immunology and The College, University of Chicago, Chicago, Illinois, United States of America

Competing Interests

DPJ and Jacobus Pharmaceutical Company are progressing JPC-2056 for the treatment of malaria. The other authors declare that they have no competing financial interests.

Author Contributions

Conceived and designed the experiments: RM PR CR SM GS WM DR JD JF SQ. Performed the experiments: SM EM GS HH MK JD JF SQ SL. Analyzed the data: RM PR CR SM EM GS WM HH DR MK JD JF SQ SL. Contributed reagents/materials/analysis tools: RM PR GS WM JD SQ. Wrote the paper: RM PR CR SM EM GS WM HH DR MK JD JF SQ SL.