Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disrupts Egg Production in Schistosoma mansoni

Ravi S. Kasinathan; William M. Morgan; Robert M. Greenberg

doi:10.1371/journal.pntd.0001425

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Open Access

Peer-reviewed

Research Article

Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disrupts Egg Production in Schistosoma mansoni

Ravi S. Kasinathan,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
William M. Morgan,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Robert M. Greenberg

* E-mail: rgree@vet.upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Genetic Knockdown and Pharmacological Inhibition of Parasite Multidrug Resistance Transporters Disrupts Egg Production in Schistosoma mansoni

Ravi S. Kasinathan,
William M. Morgan,
Robert M. Greenberg

Published: December 6, 2011
https://doi.org/10.1371/journal.pntd.0001425

About the Authors

Ravi S. Kasinathan

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

William M. Morgan

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Robert M. Greenberg

* E-mail: rgree@vet.upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RSK RMG. Performed the experiments: RSK WMM RMG. Analyzed the data: RSK WMM RMG. Wrote the paper: RSK RMG.

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Eggs
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Small interfering RNA
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Schistosoma
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Schistosoma mansoni
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Parasitic diseases
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Granulomas
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Schistosomiasis
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Drug therapy
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