Vaccination with DNA Plasmids Expressing Gn Coupled to C3d or Alphavirus Replicons Expressing Gn Protects Mice against Rift Valley Fever Virus

Nitin Bhardwaj; Mark T. Heise; Ted M. Ross

doi:10.1371/journal.pntd.0000725

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Open Access

Peer-reviewed

Research Article

Vaccination with DNA Plasmids Expressing Gn Coupled to C3d or Alphavirus Replicons Expressing Gn Protects Mice against Rift Valley Fever Virus

Nitin Bhardwaj,

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Mark T. Heise,

Affiliation Department of Microbiology and Immunology, The Carolina Vaccine Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Ted M. Ross

* E-mail: tmr15@pitt.edu

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

Vaccination with DNA Plasmids Expressing Gn Coupled to C3d or Alphavirus Replicons Expressing Gn Protects Mice against Rift Valley Fever Virus

Nitin Bhardwaj,
Mark T. Heise,
Ted M. Ross

Published: June 22, 2010
https://doi.org/10.1371/journal.pntd.0000725

About the Authors

Nitin Bhardwaj

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Mark T. Heise

Affiliation Department of Microbiology and Immunology, The Carolina Vaccine Institute, University of North Carolina, Chapel Hill, North Carolina, United States of America

Ted M. Ross

* E-mail: tmr15@pitt.edu

Affiliations Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NB MTH TMR. Performed the experiments: NB. Analyzed the data: NB MTH TMR. Contributed reagents/materials/analysis tools: MTH. Wrote the paper: NB MTH TMR.

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Rift Valley fever virus
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Viral vaccines
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Antibodies
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Vaccination and immunization
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Enzyme-linked immunoassays
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Immune response
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Vaccines
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