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Table of Contents

June 2008

Cover

Drug Development for Maternal Health.
Issue Image

The PLoS Medicine editorial this month argues that there are currently few incentives to develop new treatments for maternal health, and that political will is needed to support alternative approaches to those driven by the market. The editorial cites an analysis published earlier this year in PLoS Medicine, which found that between 1980 and 2007 only 17 new drugs were under active development for maternal health indications—less than 3% of the pipeline in cardiovascular health (Fisk et al., e22).

The "Catch 22" of the lack of effective treatments for tropical diseases in pregnancy is examined in an essay in this issue (White et al., e133). Risk aversion, among other factors, has led to the exclusion of pregnant women from clinical trials. As such, the authors argue, we don't know enough about the suitability for pregnant women of even well-established drugs.

Image Credit: Image by Valarie Apperson at Flickr.com

Editorial

Drug Development for Maternal Health Cannot Be Left to the Whims of the Market

The PLoS Medicine Editors

PLOS Medicine: published June 24, 2008 | https://doi.org/10.1371/journal.pmed.0050140

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  2. New Medicines for Tropical Diseases in Pregnancy: Catch-22
  3. The “Other” Neglected Diseases in Global Public Health: Surgical Conditions in Sub-Saharan Africa
  4. Market Failure and the Poverty of New Drugs in Maternal Health

Essays

New Medicines for Tropical Diseases in Pregnancy: Catch-22

Nicholas J White, Rose M McGready, François H Nosten

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050133

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Ethical Implications of Modifying Lethal Injection Protocols

Leonidas G Koniaris, Kenneth W Goodman, Jeremy Sugarman, Uzoezi Ozomaro, Jonathan Sheldon, Teresa A Zimmers

PLOS Medicine: published June 10, 2008 | https://doi.org/10.1371/journal.pmed.0050126

Neglected Diseases

The “Other” Neglected Diseases in Global Public Health: Surgical Conditions in Sub-Saharan Africa

Doruk Ozgediz, Robert Riviello

PLOS Medicine: published June 3, 2008 | https://doi.org/10.1371/journal.pmed.0050121

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Perspectives

Subnational Burden of Disease Studies: Mexico Leads the Way

Martin Tobias

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050138

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  1. Characterizing the Epidemiological Transition in Mexico: National and Subnational Burden of Diseases, Injuries, and Risk Factors

How Might Cocaine Interfere with Brain Development?

Steven E Hyman

PLOS Medicine: published June 10, 2008 | https://doi.org/10.1371/journal.pmed.0050130

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Health in Action

Adapting the DOTS Framework for Tuberculosis Control to the Management of Non-Communicable Diseases in Sub-Saharan Africa

Anthony D Harries, Andreas Jahn, Rony Zachariah, Donald Enarson

PLOS Medicine: published June 10, 2008 | https://doi.org/10.1371/journal.pmed.0050124

Policy Forum

Coverage of Cervical Cancer Screening in 57 Countries: Low Average Levels and Large Inequalities

Emmanuela Gakidou, Stella Nordhagen, Ziad Obermeyer

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050132

Guidelines and Guidance

Guidelines for Reporting Health Research: The EQUATOR Network's Survey of Guideline Authors

Iveta Simera, Douglas G Altman, David Moher, Kenneth F Schulz, John Hoey

PLOS Medicine: published June 24, 2008 | https://doi.org/10.1371/journal.pmed.0050139

Research in Translation

Severe Vivax Malaria: Newly Recognised or Rediscovered?

Stephen J Rogerson, Richard Carter

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050136

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  1. Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia
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Melanoma: What Are the Gaps in Our Knowledge?

Jonathan L Rees

PLOS Medicine: published June 3, 2008 | https://doi.org/10.1371/journal.pmed.0050122

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Research Articles

Plasmodium vivax and Mixed Infections Are Associated with Severe Malaria in Children: A Prospective Cohort Study from Papua New Guinea

Blaise Genton, Valérie D'Acremont, Lawrence Rare, Kay Baea, John C Reeder, Michael P Alpers, Ivo Müller

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050127

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Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia

Emiliana Tjitra, Nicholas M Anstey, Paulus Sugiarto, Noah Warikar, Enny Kenangalem, Muhammad Karyana, Daniel A Lampah, Ric N Price

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050128

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Characterizing the Epidemiological Transition in Mexico: National and Subnational Burden of Diseases, Injuries, and Risk Factors

Gretchen Stevens, Rodrigo H Dias, Kevin J. A Thomas, Juan A Rivera, Natalie Carvalho, Simón Barquera, Kenneth Hill, Majid Ezzati

PLOS Medicine: published June 17, 2008 | https://doi.org/10.1371/journal.pmed.0050125

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  2. Correction: Characterizing the Epidemiological Transition in Mexico: National and Subnational Burden of Diseases, Injuries, and Risk Factors

The Safety of Adult Male Circumcision in HIV-Infected and Uninfected Men in Rakai, Uganda

Godfrey Kigozi, Ronald H Gray, Maria J Wawer, David Serwadda, Frederick Makumbi, Stephen Watya, Fred Nalugoda, Noah Kiwanuka, Lawrence H Moulton, Michael Z Chen, Nelson K Sewankambo, Fred Wabwire-Mangen, Melanie C Bacon, Renee Ridzon, Pius Opendi, Victor Sempijja, Absolom Settuba, Denis Buwembo, Valerian Kiggundu, Margaret Anyokorit, James Nkale, Nehemia Kighoma, Blake Charvat

PLOS Medicine: published June 3, 2008 | https://doi.org/10.1371/journal.pmed.0050116

Effect of a Brief Video Intervention on Incident Infection among Patients Attending Sexually Transmitted Disease Clinics

Lee Warner, Jeffrey D Klausner, Cornelis A Rietmeijer, C. Kevin Malotte, Lydia O'Donnell, Andrew D Margolis, Gregory L Greenwood, Doug Richardson, Shelley Vrungos, Carl R O'Donnell, Craig B Borkowf, for the Safe in the City Study Group

PLOS Medicine: published June 24, 2008 | https://doi.org/10.1371/journal.pmed.0050135

How Well Do Clinical Pain Assessment Tools Reflect Pain in Infants?

Rebeccah Slater, Anne Cantarella, Linda Franck, Judith Meek, Maria Fitzgerald

PLOS Medicine: published June 24, 2008 | https://doi.org/10.1371/journal.pmed.0050129

Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

Hans Bisgaard, Angela Simpson, Colin N.A Palmer, Klaus Bønnelykke, Irwin Mclean, Somnath Mukhopadhyay, Christian B Pipper, Liselotte B Halkjaer, Brian Lipworth, Jenny Hankinson, Ashley Woodcock, Adnan Custovic

PLOS Medicine: published June 24, 2008 | https://doi.org/10.1371/journal.pmed.0050131

Improving Melanoma Classification by Integrating Genetic and Morphologic Features

Amaya Viros, Jane Fridlyand, Juergen Bauer, Konstantin Lasithiotakis, Claus Garbe, Daniel Pinkel, Boris C Bastian

PLOS Medicine: published June 3, 2008 | https://doi.org/10.1371/journal.pmed.0050120

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A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development

Vitor M Faca, Kenneth S Song, Hong Wang, Qing Zhang, Alexei L Krasnoselsky, Lisa F Newcomb, Ruben R Plentz, Sushma Gurumurthy, Mark S Redston, Sharon J Pitteri, Sandra R Pereira-Faca, Renee C Ireton, Hiroyuki Katayama, Veronika Glukhova, Douglas Phanstiel, Dean E Brenner, Michelle A Anderson, David Misek, Nathalie Scholler, Nicole D Urban, Matt J Barnett, Cim Edelstein, Gary E Goodman, Mark D Thornquist, Martin W McIntosh, Ronald A DePinho, Nabeel Bardeesy, Samir M Hanash

PLOS Medicine: published June 10, 2008 | https://doi.org/10.1371/journal.pmed.0050123

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

Almut Grenz, Hartmut Osswald, Tobias Eckle, Dan Yang, Hua Zhang, Zung Vu Tran, Karin Klingel, Katya Ravid, Holger K Eltzschig

PLOS Medicine: published June 24, 2008 | https://doi.org/10.1371/journal.pmed.0050137

A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine

Chun-Ting Lee, Jia Chen, Teruo Hayashi, Shang-Yi Tsai, Joseph F Sanchez, Stacie L Errico, Rose Amable, Tsung-Ping Su, Ross H Lowe, Marilyn A Huestis, James Shen, Kevin G Becker, Herbert M Geller, William J Freed

PLOS Medicine: published June 10, 2008 | https://doi.org/10.1371/journal.pmed.0050117

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Correction

Correction: Resisting Immune Exhaustion in HIV-1 Infection

Sarah Rowland-Jones, Thushan de Silva

PLOS Medicine: published June 3, 2008 | https://doi.org/10.1371/journal.pmed.0050134

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