Despite heavy research investments, there has been little if any progress towards an effective treatment for Alzheimer's disease, and leading pharmaceutical company Pfizer recently shuttered its research programs into the disease. On the one-year anniversary of the Special Issue on Dementia, the PLOS Medicine Editors discuss the challenges of addressing a growing population with Alzheimer disease and dementia amidst disappointing news from the pharmaceutical industry. Repeated failures demand new strategies, and an aging population requires action, not surrender.
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Editorial
Setbacks in Alzheimer research demand new strategies, not surrender
PLOS Medicine: published February 27, 2018 | https://doi.org/10.1371/journal.pmed.1002518
Perspective
Preventing cholera outbreaks through early targeted interventions
PLOS Medicine: published February 27, 2018 | https://doi.org/10.1371/journal.pmed.1002510
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Research Articles
Susceptibility of Neisseria gonorrhoeae to azithromycin and ceftriaxone in China: A retrospective study of national surveillance data from 2013 to 2016
PLOS Medicine: published February 6, 2018 | https://doi.org/10.1371/journal.pmed.1002499
Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing homes: A cluster-randomised controlled trial
PLOS Medicine: published February 6, 2018 | https://doi.org/10.1371/journal.pmed.1002500
Population impact of lung cancer screening in the United States: Projections from a microsimulation model
PLOS Medicine: published February 7, 2018 | https://doi.org/10.1371/journal.pmed.1002506
Perfluoroalkyl substances and changes in body weight and resting metabolic rate in response to weight-loss diets: A prospective study
PLOS Medicine: published February 13, 2018 | https://doi.org/10.1371/journal.pmed.1002502
Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis
PLOS Medicine: published February 20, 2018 | https://doi.org/10.1371/journal.pmed.1002505
The 2014–2015 Ebola virus disease outbreak and primary healthcare delivery in Liberia: Time-series analyses for 2010–2016
PLOS Medicine: published February 20, 2018 | https://doi.org/10.1371/journal.pmed.1002508
The potential impact of case-area targeted interventions in response to cholera outbreaks: A modeling study
PLOS Medicine: published February 27, 2018 | https://doi.org/10.1371/journal.pmed.1002509
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Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies
PLOS Medicine: published February 27, 2018 | https://doi.org/10.1371/journal.pmed.1002511
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Prevalence of sexually transmitted infections among young people in South Africa: A nested survey in a health and demographic surveillance site
PLOS Medicine: published February 27, 2018 | https://doi.org/10.1371/journal.pmed.1002512
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Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis
PLOS Medicine: published February 28, 2018 | https://doi.org/10.1371/journal.pmed.1002507