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Table of Contents: September 2009

In this month's Editorial the PLoS Medicine Editors discuss the importance of valid negative results, and their immediate and open availability, in maintaining the integrity of the medical literature, especially when clinical effectiveness is at issue. The Editorial suggests that physicians mindful of Hippocrates's vow "first do no harm" should appreciate that a study "that questions the accepted or desired way of doing things can be at least as important as one that supports a new approach." Given the US movement to undertake comparative effectiveness research (CER)—which calls for a wide range of study designs to "assist consumers, clinicians and policy-makers in making informed decisions"—the Editorial argues for transparency in the design and reporting of all types of research, including data that cast doubt on prevailing practices.

Image Credit: Image adapted from photograph by Tony Fischer, Carpe Diem Photography, at flickr.com

Policy Forums

Considering Usual Medical Care in Clinical Trial Design

Liza Dawson, Deborah A. Zarin, Ezekiel J. Emanuel, Lawrence M. Friedman, Bimal Chaudhari, Steven N. Goodman

Research in Translation

Should Burden of Disease Estimates Include Cannabis Use as a Risk Factor for Psychosis?

Louisa Degenhardt, Wayne D. Hall, Michael Lynskey, John McGrath, Jennifer McLaren, Bianca Calabria, Harvey Whiteford, Theo Vos

Research Articles

The Impact of the Demographic Transition on Dengue in Thailand: Insights from a Statistical Analysis and Mathematical Modeling

Derek A. T. Cummings, Sopon Iamsirithaworn, Justin T. Lessler, Aidan McDermott, Rungnapa Prasanthong, Ananda Nisalak, Richard G. Jarman, Donald S. Burke, Robert V. Gibbons

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Cholinesterase Inhibitors and Hospitalization for Bradycardia: A Population-Based Study

Laura Y. Park-Wyllie, Muhammad M. Mamdani, Ping Li, Sudeep S. Gill, Andreas Laupacis, David N. Juurlink

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  1. Ensuring Integrity in Comparative Effectiveness Research: Accentuate the Negative

Trial Publication after Registration in ClinicalTrials.Gov: A Cross-Sectional Analysis

Joseph S. Ross, Gregory K. Mulvey, Elizabeth M. Hines, Steven E. Nissen, Harlan M. Krumholz

The Risk of Fractures Associated with Thiazolidinediones: A Self-controlled Case-Series Study

Ian J. Douglas, Stephen J. Evans, Stuart Pocock, Liam Smeeth

Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6

William Whiteley, Caroline Jackson, Steff Lewis, Gordon Lowe, Ann Rumley, Peter Sandercock, Joanna Wardlaw, Martin Dennis, Cathie Sudlow

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