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Table of Contents: December 2006

A germline mutation in the palladin gene associated with familial pancreatic cancer causes abnormal distribution of the cytoskeletal palladin protein in transfected cells, as shown here. The research article by Pogue-Geile et al. reports the identification of the mutation in a large kindred with pancreatic cancer, as well as the findings that palladin is overexpressed in sporadic pancreatic cancers and that cells expressing the mutant protein have an increased ability to migrate.

Image Credit: Cover design by Natalie Davis, Public Library of Science, with images taken from Pogue-Geile et al.

Essays

Do We Need a World Health Insurance to Realise the Right to Health?

Gorik Ooms, Katharine Derderian, David Melody

Intensive Insulin Therapy in Intensive Care: An Example of the Struggle to Implement Evidence-Based Medicine

Marcus J Schultz, Annick A. N. M Royakkers, Marcel Levi, Hazra S Moeniralam, Peter E Spronk

Perspectives

Mining Methylation for Early Detection of Common Cancers

Romulo M Brena, Christoph Plass, Joseph F Costello

Health in Action

Healthy Penis: San Francisco's Social Marketing Campaign to Increase Syphilis Testing among Gay and Bisexual Men

Katherine Ahrens, Charlotte K Kent, Jorge A Montoya, Harlan Rotblatt, Jacque McCright, Peter Kerndt, Jeffrey D Klausner

Learning Forums

Ophthalmoplegia and Slurred Speech in an Intravenous Drug User

Jaime Vera, Anke Hensiek, Charles Woodrow, Francesca Crawley, Sanjeev Krishna

Hypogammaglobulinemia with Facial Edema

Adina Kay Knight, Lloyd Mayer, Andrew G Franks Jr., Charlotte Cunningham-Rundles

Research Articles

Palladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism

Kay L Pogue-Geile, Ru Chen, Mary P Bronner, Tatjana Crnogorac-Jurcevic, Kara White Moyes, Sally Dowen, Carol A Otey, David A Crispin, Ryan D George, David C Whitcomb, Teresa A Brentnall

A Gene Expression Signature Predicts Survival of Patients with Stage I Non-Small Cell Lung Cancer

Yan Lu, William Lemon, Peng-Yuan Liu, Yijun Yi, Carl Morrison, Ping Yang, Zhifu Sun, Janos Szoke, William L Gerald, Mark Watson, Ramaswamy Govindan, Ming You

A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

David S Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna

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Correspondence

Corrections

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