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“Antibiotics Are Not Automatic Anymore”—The French National Campaign To Cut Antibiotic Overuse

“Antibiotics Are Not Automatic Anymore”—The French National Campaign To Cut Antibiotic Overuse

  • Benedikt Huttner, 
  • Stephan Harbarth
PLOS
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Linked Research Article

This Perspective discusses the following new study published in PLoS Medicine:

Sabuncu E, David J, Bernède-Bauduin C, Pépin S, Leroy M, Boëlle P-Y, Watier L, Guillemot D (2009) Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002–2007. PLoS Med 6(6): e1000084. doi:10.1371/journal.pmed.1000084

Didier Guillemot and colleagues describe the evaluation of a nationwide programme in France aimed at decreasing unnecessary outpatient prescriptions for antibiotics. The campaign was successful, particularly in reducing prescriptions for children.

Outpatient Antibiotic Use and Antibiotic Resistance

Antibiotic resistance is an important public health concern [1]. Antibiotics are one of the most commonly prescribed drug classes worldwide, with considerable variation in outpatient antibiotic use between countries [2]. Viral respiratory tract infections drive antibiotic overprescribing in the outpatient setting, and this overprescribing is also influenced by patient demand and expectations [3],[4].

There has been great interest in the public health community in avoiding unnecessary prescriptions, not only by providing treatment guidelines and decision support to physicians, but also by educating the public about appropriate antibiotic use. But the most effective strategy to achieve this goal remains unknown [5]. In the 1990s, one of the first national campaigns to reduce antibiotic prescribing resulted in a decrease in antibiotic use and penicillin-resistant Streptococcus pneumoniae in Iceland [6]. Since that time, there have been many other public campaigns, but published data about their impact remain scarce. Until now, the best evidence correlating a national campaign to a reduction in antibiotic use came from Belgium, where yearly mass media campaigns were associated with a 36% reduction in antibiotic prescriptions between 1999–2000 and 2006–2007 [7].

The French National Campaign To Reduce Unnecessary Antibiotic Use

In a new study published in this issue of PLoS Medicine, Didier Guillemot and colleagues analyze the impact of a similar campaign in France, which used to be known for the highest rates of antibiotic use and pneumococcal resistance in Europe [8],[9]. In 2001, French policy makers and public health authorities launched a coordinated and multifaceted strategy for the control of antimicrobial resistance. One of the key interventions was a yearly campaign targeting the public via mass media, conveying the message that “Antibiotics Are Not Automatic” (especially for viral respiratory tract infections). Simultaneously, the streptococcal rapid antigen test and treatment guidelines were promoted among health care professionals. A substantial number of primary care physicians were targeted by one-on-one educational sessions known as “academic detailing”.

Analyzing prescribing data provided by the national health insurance (covering over 90% of the population) for two winters before and five winters after the launch of the first campaign, Guillemot and colleagues observed a decline by 26.5% in the number of antibiotic prescriptions, surpassing even the national target of a 25% reduction over five years. The decrease was seen in all French regions and age groups, with the highest decrease observed in children. Despite this decline in antibiotic use, a relative increase in fluoroquinolone use by 12.8% was observed, indicating the possibility that the choice of antibiotic may have become less appropriate for certain treatment indications.

Strengths and Limitations of the Study

This study provides the largest and most sophisticated analysis published thus far correlating a nationwide public campaign to decreased antibiotic use over an extended period of time. The researchers address many potential sources of bias and confounding [10].

Nevertheless, some issues warrant further comment. Although it is likely that the reduction in antibiotic prescribing was causally related to the campaign, the ecological before-and-after study design cannot provide definitive proof of causality. As mentioned by the authors, in a few European countries a decrease in antibiotic use was also seen without major campaigns. The paper does not provide any information about surrogate markers that might explain the campaign's success, such as the public's awareness of the campaign or changes in knowledge and attitudes among physicians and the public. A limitation inherent to any multifaceted, complex intervention is that no clue is provided to identify which of the numerous interventions were most effective and could be recommended to other countries. Finally, although the impact on antibiotic prescriptions is impressive, the effect on antimicrobial resistance is still unclear and difficult to separate from the effect of the conjugate pneumococcal vaccine [11],[12].

Cost Issues

Guillemot and colleagues report that developing and conducting the campaign cost 500 million euros over six years, which seems extremely costly considering that the Belgian campaign cost only about 400,000 euros per year [7]. But without more detailed cost-benefit analyses, this cost information should be interpreted with caution. It is, however, noteworthy that the reduction in antibiotic costs in France outweighed the cost of the public campaign to reduce prescribing.

The amount of money spent by the pharmaceutical industry to promote antibiotics should also be considered when assessing cost issues. Unfortunately, we do not have access to these figures for Europe. However, in the United States in 1998, it was estimated that pharmaceutical companies spent about US$1.6 billion to promote antibiotics, an amount that vastly exceeds any budget allocated to antibiotic campaigns [13].

Is the French Experience an Example for Other Countries To Follow?

Overall, the results of the French public campaign are very encouraging and confirm those of the Belgian campaign: in countries with high baseline antibiotic use, sustained and multifaceted campaigns using mass media as well as targeting physicians can decrease antibiotic use substantially. Nonetheless, given the variations in antibiotic usage patterns, sociocultural determinants, and health care systems, different approaches are warranted for different countries [3]. Future campaign managers are certainly well-advised to apply social marketing concepts to identify the optimal approach for their own country [14]. We should not forget, however, that some national campaigns (e.g., Greece, Spain, England, Australia) failed to show a major impact on antibiotic prescriptions, although few of these data have been published [15],[16]. On the other hand, Sweden succeeded in reducing antibiotic use by a comprehensive program without a public campaign component [17].

Next Steps

Since the ultimate goal of any campaign to reduce antibiotic use is to curb antibiotic resistance, more longitudinal and modeling studies are needed. Realistically, these studies may require individual patient data from small-scale surveillance networks, including monitoring of potential adverse effects of reduced prescribing.

All in all, the French have to be congratulated for their success story demonstrating that, if policy makers and opinion leaders are serious about reducing antibiotic misuse, this goal can be achieved by well-coordinated national efforts. Throughout the world, we should no longer accept antibiotic misuse and resistance as “automatic”.

Acknowledgments

This article is dedicated to the memory of Prof. Jean-Claude Pechère, who died in Geneva, Switzerland, on November 29, 2008, and who devoted much of his time and passion to the improved use of antimicrobial agents.

Author Contributions

ICMJE criteria for authorship read and met: BH SH. Wrote the first draft of the paper: BH. Contributed to the writing of the paper: SH.

References

  1. 1. Harbarth S, Samore MH (2005) Antimicrobial resistance determinants and future control. Emerg Infect Dis 11: 794–801.S. HarbarthMH Samore2005Antimicrobial resistance determinants and future control.Emerg Infect Dis11794801
  2. 2. Goossens H, Ferech M, Coenen S, Stephens P (2007) Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries. Clin Infect Dis 44: 1091–1095.H. GoossensM. FerechS. CoenenP. Stephens2007Comparison of outpatient systemic antibacterial use in 2004 in the United States and 27 European countries.Clin Infect Dis4410911095
  3. 3. Harbarth S, Albrich W, Brun-Buisson C (2002) Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: A sociocultural perspective. Emerg Infect Dis 8: 1460–1467.S. HarbarthW. AlbrichC. Brun-Buisson2002Outpatient antibiotic use and prevalence of antibiotic-resistant pneumococci in France and Germany: A sociocultural perspective.Emerg Infect Dis814601467
  4. 4. Akkerman AE, Kuyvenhoven MM, van der Wouden JC, Verheij TJ (2005) Determinants of antibiotic overprescribing in respiratory tract infections in general practice. J Antimicrob Chemother 56: 930–936.AE AkkermanMM KuyvenhovenJC van der WoudenTJ Verheij2005Determinants of antibiotic overprescribing in respiratory tract infections in general practice.J Antimicrob Chemother56930936
  5. 5. Ranji SR, Steinman MA, Shojania KG, Gonzales R (2008) Interventions to reduce unnecessary antibiotic prescribing: A systematic review and quantitative analysis. Med Care 46: 847–862.SR RanjiMA SteinmanKG ShojaniaR. Gonzales2008Interventions to reduce unnecessary antibiotic prescribing: A systematic review and quantitative analysis.Med Care46847862
  6. 6. Kristinsson KG (1999) Modification of prescribers' behavior: The Icelandic approach. Clin Microbiol Infect 5: (Suppl 4)S43–S47.KG Kristinsson1999Modification of prescribers' behavior: The Icelandic approach.Clin Microbiol Infect5(Suppl 4)S43S47
  7. 7. Goossens H, Coenen S, Costers M, De Corte S, De Sutter A, et al. (2008) Achievements of the Belgian Antibiotic Policy Coordination Committee (BAPCOC). Euro Surveill 13: 19036.H. GoossensS. CoenenM. CostersS. De CorteA. De Sutter2008Achievements of the Belgian Antibiotic Policy Coordination Committee (BAPCOC).Euro Surveill1319036
  8. 8. Sabuncu E, David J, Bernède-Bauduin C, Pépin S, Leroy M, et al. (2009) Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002–2007. PLoS Med 6: e1000084.E. SabuncuJ. DavidC. Bernède-BauduinS. PépinM. Leroy2009Significant reduction of antibiotic use in the community after a nationwide campaign in France, 2002–2007.PLoS Med6e1000084
  9. 9. Goossens H, Ferech M, Vander Stichele R, Elseviers M (2005) Outpatient antibiotic use in Europe and association with resistance: A cross-national database study. Lancet 365: 579–587.H. GoossensM. FerechR. Vander SticheleM. Elseviers2005Outpatient antibiotic use in Europe and association with resistance: A cross-national database study.Lancet365579587
  10. 10. Cosby JL, Francis N, Butler CC (2007) The role of evidence in the decline of antibiotic use for common respiratory infections in primary care. Lancet Infect Dis 7: 749–756.JL CosbyN. FrancisCC Butler2007The role of evidence in the decline of antibiotic use for common respiratory infections in primary care.Lancet Infect Dis7749756
  11. 11. Cohen R, Levy C, de La Rocque F, Gelbert N, Wollner A, et al. (2006) Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media. Pediatr Infect Dis J 25: 1001–1007.R. CohenC. LevyF. de La RocqueN. GelbertA. Wollner2006Impact of pneumococcal conjugate vaccine and of reduction of antibiotic use on nasopharyngeal carriage of nonsusceptible pneumococci in children with acute otitis media.Pediatr Infect Dis J2510011007
  12. 12. Dagan R, Klugman KP (2008) Impact of conjugate pneumococcal vaccines on antibiotic resistance. Lancet Infect Dis 8: 785–795.R. DaganKP Klugman2008Impact of conjugate pneumococcal vaccines on antibiotic resistance.Lancet Infect Dis8785795
  13. 13. Ma J, Stafford RS, Cockburn IM, Finkelstein SN (2003) A statistical analysis of the magnitude and composition of drug promotion in the United States in 1998. Clin Ther 25: 1503–1517.J. MaRS StaffordIM CockburnSN Finkelstein2003A statistical analysis of the magnitude and composition of drug promotion in the United States in 1998.Clin Ther2515031517
  14. 14. Edgar T, Boyd SD, Palame MJ (2009) Sustainability for behaviour change in the fight against antibiotic resistance: A social marketing framework. J Antimicrob Chemother 63: 230–237.T. EdgarSD BoydMJ Palame2009Sustainability for behaviour change in the fight against antibiotic resistance: A social marketing framework.J Antimicrob Chemother63230237
  15. 15. Davey P, Ferech M, Ansari F, Muller A, Goossens H (2008) Outpatient antibiotic use in the four administrations of the UK: Cross-sectional and longitudinal analysis. J Antimicrob Chemother 62: 1441–1447.P. DaveyM. FerechF. AnsariA. MullerH. Goossens2008Outpatient antibiotic use in the four administrations of the UK: Cross-sectional and longitudinal analysis.J Antimicrob Chemother6214411447
  16. 16. Weekes L, Mackson J, Artist M, Wutzke S (2007) An ongoing national programme to reduce antibiotic prescription and use. Microbiol Australia 28: 201–204.L. WeekesJ. MacksonM. ArtistS. Wutzke2007An ongoing national programme to reduce antibiotic prescription and use.Microbiol Australia28201204
  17. 17. Molstad S, Erntell M, Hanberger H, Melander E, Norman C, et al. (2008) Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme. Lancet Infect Dis 8: 125–132.S. MolstadM. ErntellH. HanbergerE. MelanderC. Norman2008Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme.Lancet Infect Dis8125132