Figures
Mutant Palladin Protein in Pancreatic Cancer.
A germline mutation in the palladin gene associated with familial pancreatic cancer causes abnormal distribution of the cytoskeletal palladin protein in transfected cells, as shown here. The research article by Pogue-Geile et al. reports the identification of the mutation in a large kindred with pancreatic cancer, as well as the findings that palladin is overexpressed in sporadic pancreatic cancers and that cells expressing the mutant protein have an increased ability to migrate.
Image Credit: Cover design by Natalie Davis, Public Library of Science, with images taken from Pogue-Geile et al.
Citation: (2006) PLoS Medicine Issue Image | Vol. 3(12) December 2006. PLoS Med 3(12): ev03.i12. https://doi.org/10.1371/image.pmed.v03.i12
Published: December 26, 2006
Copyright: © 2006 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A germline mutation in the palladin gene associated with familial pancreatic cancer causes abnormal distribution of the cytoskeletal palladin protein in transfected cells, as shown here. The research article by Pogue-Geile et al. reports the identification of the mutation in a large kindred with pancreatic cancer, as well as the findings that palladin is overexpressed in sporadic pancreatic cancers and that cells expressing the mutant protein have an increased ability to migrate.
Image Credit: Cover design by Natalie Davis, Public Library of Science, with images taken from Pogue-Geile et al.