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The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Prospective Cohort Studies

  • Marc A. Rodger ,

    mrodger@ohri.ca

    Affiliations Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology/Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

  • Marisol T. Betancourt,

    Affiliations Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology/Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

  • Peter Clark,

    Affiliation Department of Transfusion Medicine, Ninewells, Hospital and Medical School, Dundee, United Kingdom

  • Pelle G. Lindqvist,

    Affiliation Department of Obstetrics and Gynecology, Karolinska Hospital, Huddinge, Sweden

  • Donna Dizon-Townson,

    Affiliation National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, Bethesda, Maryland

  • Joanne Said,

    Affiliations Department of Perinatal Medicine, The Royal Women's Hospital, Carlton, Victoria Australia, Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia

  • Uri Seligsohn,

    Affiliation The Amalia Biron Thrombosis and Hemostasis Research Institute, the Chaim Sheba Medical Center, Tel Hashomer, Israel

  • Marc Carrier,

    Affiliations Thrombosis Program, Division of Hematology, Departments of Medicine, Obstetrics and Gynecology and Epidemiology/Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, Clinical Epidemiology Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada

  • Ophira Salomon,

    Affiliation The Amalia Biron Thrombosis and Hemostasis Research Institute, the Chaim Sheba Medical Center, Tel Hashomer, Israel

  • Ian A. Greer

    Affiliation Hull York Medical School, York, United Kingdom

The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Prospective Cohort Studies

  • Marc A. Rodger, 
  • Marisol T. Betancourt, 
  • Peter Clark, 
  • Pelle G. Lindqvist, 
  • Donna Dizon-Townson, 
  • Joanne Said, 
  • Uri Seligsohn, 
  • Marc Carrier, 
  • Ophira Salomon, 
  • Ian A. Greer
PLOS
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