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Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

  • Hans Bisgaard ,

    To whom correspondence should be addressed. E-mail: bisgaard@copsac.com

    Affiliation Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

  • Angela Simpson,

    Affiliation School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

  • Colin N.A Palmer,

    Affiliation Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

  • Klaus Bønnelykke,

    Affiliation Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

  • Irwin Mclean,

    Affiliation Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

  • Somnath Mukhopadhyay,

    Affiliation Royal Alexandra Children's Hospital, Brighton and Sussex Medical School, Brighton, United Kingdom

  • Christian B Pipper,

    Affiliation Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

  • Liselotte B Halkjaer,

    Affiliation Copenhagen Prospective Studies on Asthma in Childhood, Danish Paediatric Asthma Centre, Copenhagen, University Hospital Gentofte, Copenhagen, Denmark

  • Brian Lipworth,

    Affiliation Asthma and Allergy Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom

  • Jenny Hankinson,

    Affiliation School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

  • Ashley Woodcock,

    Affiliation School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

  • Adnan Custovic

    Affiliation School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom

Gene-Environment Interaction in the Onset of Eczema in Infancy: Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure

  • Hans Bisgaard, 
  • Angela Simpson, 
  • Colin N.A Palmer, 
  • Klaus Bønnelykke, 
  • Irwin Mclean, 
  • Somnath Mukhopadhyay, 
  • Christian B Pipper, 
  • Liselotte B Halkjaer, 
  • Brian Lipworth, 
  • Jenny Hankinson
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