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Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

  • Matthew L Hemming,

    Affiliation Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

  • Michaela Patterson,

    Affiliation Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

  • Casper Reske-Nielsen,

    Affiliation Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

  • Ling Lin,

    Affiliation Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

  • Ole Isacson,

    Affiliation Neuroregeneration Laboratories, McLean Hospital and Harvard University Udall Parkinson's Disease Research Center of Excellence, Belmont, Massachusetts, United States of America

  • Dennis J Selkoe

    To whom correspondence should be addressed. E-mail: dselkoe@rics.bwh.harvard.edu

    Affiliation Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

  • Matthew L Hemming, 
  • Michaela Patterson, 
  • Casper Reske-Nielsen, 
  • Ling Lin, 
  • Ole Isacson, 
  • Dennis J Selkoe
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