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Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults

Fig 1

Association of genetic score using synthesis SNPs for 25(OH)D concentration with risk of diabetes in a meta-analysis of all studies per 25-nmol/l higher genetically instrumented 25(OH)D concentration.

Values shown are the odds ratios (95% CIs) per 25-nmol/l higher 25(OH)D concentration among studies stratified by latitude into northern (>50°) or southern latitude (≤50°). The area of the squares is proportional to the inverse variance of each effect size. *The effects of all SNPs on risk of diabetes in Chinese and European populations were weighted by their effects on 25(OH)D concentration. 25(OH)D, 25-hydroxyvitamin D; CCCS, Cambridgeshire case—control study; CKB, China Kadoorie Biobank; DIAGRAM, Diabetes Genetics Replication and Meta-analysis; UKB, UK Biobank.

Fig 1

doi: https://doi.org/10.1371/journal.pmed.1002566.g001