Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
Fold enrichment plots of enrichment (after removing all regions in linkage disequilibrium with HLA on Chromosome 6) versus nominal −log10(p)-values (corrected for inflation) in frontotemporal dementia (FTD) below the standard genome-wide association study threshold of p < 5 × 10−8 as a function of significance of association with 6 immune-mediated diseases.
The 6 immune-mediated diseases were Crohn disease (CD), ulcerative colitis (UC), type 1 diabetes (T1D), rheumatoid arthritis (RA), celiac disease (CeD), and psoriasis (PSOR). The levels of −log10(p) > 0, −log10(p) > 1, and −log10(p) > 2 correspond to p < 1, p < 0.1, and p < 0.01, respectively. The dark blue line indicates all SNPs.