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Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

Fig 2

“Conjunction” Manhattan plot of conjunction −log10(FDR) values for frontotemporal dementia (FTD) given 6 immune-mediated diseases.

The 6 immune-related diseases were Crohn disease (CD; FTD|CD, red), ulcerative colitis (UC, FTD|UC, orange), type 1 diabetes (T1D, FTD|T1D, teal), rheumatoid arthritis (RA, FTD|RA, green), celiac disease (CeD, FTD|CeD, magenta), and psoriasis (PSOR, FTD|PSOR, blue). SNPs with conjunction −log10(FDR) > 1.3 (i.e., FDR < 0.05) are shown with large points. A black line around the large points indicates the most significant SNP in each linkage disequilibrium block, and this SNP was annotated with the closest gene, which is listed above the symbols in each locus.

Fig 2