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Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial

Fig 1

HVTN 104 CONSORT flow diagram (A) and specimen collection schedule (B).

T1: 20 mg/kg IV q 4 weeks with 40 mg/kg IV loading; T2: 40 mg/kg IV q 8 weeks; T3 (P3): 5 mg/kg SC q 2 weeks with 40 mg/kg IV loading; T4: 10 mg/kg IV q 8 weeks; T5: 30 mg/kg IV q 8 weeks. ADCC, antibody-dependent cellular cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; CONSORT, Consolidated Standards of Reporting Trials; HVTN, HIV Vaccine Trials Network; IV, intravenous; P3, placebo group 3; q, quodque; SC, subcutaneous; T1, treatment group 1; T2, treatment group 2; T3, treatment group 3; T4, treatment group 4; T5, treatment group 5.

Fig 1

doi: https://doi.org/10.1371/journal.pmed.1002435.g001