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Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts

Fig 4

One-stage individual participant data meta-analysis.

Offspring metabolite differences in means in SD units per 1-SD higher maternal (pink) or paternal (blue) body mass index (BMI), meta-analysed across Avon Longitudinal Study of Parents and Children (ALSPAC) and Northern Finland Birth Cohort of 1986 (NFBC86) cohorts. Associations were adjusted for parental age, smoking, education, head of household social class, maternal parity, offspring age at blood collection, sex, and cohort membership. Results are shown in SD-scaled concentration units of outcome; differences in absolute concentration units are listed in S3 Table. Error bars = 95% confidence intervals (CI).

Fig 4

doi: https://doi.org/10.1371/journal.pmed.1002376.g004