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Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology–Genomic Integration Analysis

Fig 4

Accumulated prognostic value of microenvironmental heterogeneity and cancer TP53 mutation in high-grade breast tumors.

(A) Kaplan–Meier curves illustrating the duration of disease-specific survival according to microenvironmental heterogeneity (EDI, left panel), TP53 mutation (middle panel), and both (right panel) in 507 grade 3 breast tumors. MUT, mutant; WT, wild-type. (B) Schematic diagram to illustrate the hypothesized temporal progression of invasive breast cancer with loss of TP53 tumor suppressor functions as an early-stage event and spatial diversification of microenvironment as late-stage event.

Fig 4

doi: https://doi.org/10.1371/journal.pmed.1001961.g004