The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Figure 5
Kaplan–Meier curve for PCR-confirmed recrudescence for children from 1 up to 5 years of age exposed to a dose below or above 59 mg/kg.
Log rank test stratified by study sites p<0.001. The HR for exposure to a PIP dose below 59 mg/kg was 2.36 (95% CI 1.42–3.91), p<0.001 and the AHR 2.03 (95% CI 1.20–3.43), p = 0.008; after controlling for parasitemia and body weight.