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Leisure Time Physical Activity of Moderate to Vigorous Intensity and Mortality: A Large Pooled Cohort Analysis

Figure 1

Leisure time physical activity level and hazard ratios for mortality and gains in life expectancy after age 40.

The points shown represent the HR (A) or years of life gained (B) for each of the physical activity categories examined, and the vertical lines represent the 95% CIs for that physical activity category. The reference category for both (A) and (B) is 0.0 MET-h/wk of leisure time physical activity. The lines connecting the points help to illustrate the dose–response relationship between physical activity and risk of mortality; the shape of the association shown here is similar to that obtained using spline modeling (Figure S1). HRs were calculated in models stratified by study that used age as the underlying time scale. Multivariable models were adjusted for gender, alcohol consumption (0, 0.1–14.9, 15.0–29.9, 30.0+ g/d), education (did not complete high school, completed high school, post-high-school training, some college, completed college), marital status (married, divorced, widowed, unmarried), history of heart disease, history of cancer, BMI (<18.5, 18.5–19.9, 20–22.4, 22.5–24.9, 25–27.4, 27.5–29.9, 30+ kg/m2), and smoking status (never, former, current). Years of life expectancy gained after age 40 were derived using direct adjusted survival curves [31],[32] for participants who were 40+ y of age at baseline (97.5% of participants).

Figure 1

doi: https://doi.org/10.1371/journal.pmed.1001335.g001