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Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics Study

Figure 4

Statistical significance and reproducibility for the IHRIP data.

(a) The histogram of 54,675 p-values from our framework. (b) The number of significant probesets at various FDR cut-offs. These results indicate strong statistical significance. (c) Our strategy to assess reproducibility. (d) Reproducibility assessment of our framework: 20 quantile-quantile plots for 20 cross-validations. Consistently large downward deviations from the diagonal (dashed line) indicate reproducibility.

Figure 4

doi: https://doi.org/10.1371/journal.pmed.1001093.g004