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Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics Study

Figure 2

Schematic of the analysis framework.

There are three fundamental steps in the analysis framework. Step 1: characterizing phenotypes from longitudinal clinical data; Step 2: quantifying within-patient expression changes from the genomic data; and Step 3: statistical modeling and hypothesis testing to relate the two.

Figure 2

doi: https://doi.org/10.1371/journal.pmed.1001093.g002