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Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

Figure 5

Analysis of the Withdrawal Rates

(A) RR of withdrawal for any reason in adult and paediatric trials and comparison of RR of the total withdrawal rate in children and adults.

(B) Comparison of RR of the adverse events withdrawal rate in children and adults.

(C) Comparison of RR of the withdrawal rate related to seizure aggravation in children and adults.

(D) Mean withdrawal rate for either any reasons, adverse events or seizure aggravation with placebo and with AED in adult and paediatric trials. * p < 0.001 (logistic regression).

I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.

Figure 5

doi: https://doi.org/10.1371/journal.pmed.0050166.g005