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Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

Figure 4

Analysis of the Seizure-Free Rate

(A) RR of seizure-free rate in adult and paediatric trials and comparison of RR of seizure-free rate in children and adults.

(B) Mean seizure-free rate with placebo and with AED in adult and paediatric trials.

I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.

Figure 4

doi: https://doi.org/10.1371/journal.pmed.0050166.g004