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Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

Figure 3

Analysis of the 50% Responder Rate Including All Dosages

(A) RR of 50% responder rate in adult and paediatric trials and comparison of RR of 50% responder rate in children and adults.

(B) Mean 50% responder rate with placebo and with AED in adult and paediatric trials. * p < 0.001 (logistic regression).

I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.

Figure 3

doi: https://doi.org/10.1371/journal.pmed.0050166.g003