Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy
(A) RR of 50% responder rate in adult and paediatric trials and comparison of RR of 50% responder rate in children and adults.
(B) Mean 50% responder rate with placebo and with AED in adult and paediatric trials. * p < 0.001 (logistic regression).
I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.