Cytological and Transcript Analyses Reveal Fat and Lazy Persister-Like Bacilli in Tuberculous Sputum
Figure 3
Genes Required for Aerobic Respiration and Ribosomal Function Show Decreased Expression in Sputum Compared with Aerobic Growth while Genes Involved in Lipid Metabolism Were Induced
Box and whisker plots showing the distribution of expression ratios (log2 scale) of (A) 21 aerobic respiration genes and (B) 45 ribosomal genes in NRP2 and sputum relative to aerobic growth using functional classifications defined by Cole et al., 1998 [24]; also (C) 64 genes that may be involved in cholesterol catabolism [38] and (D) 45 genes in the fadB, echA, fadE, and fadA families, which may be involved in the β-oxidation of fatty acids. *Significant difference (p < 0.01) between NRP2 or sputum compared to aerobic; #Significant difference (p < 0.01) between NRP2 and sputum.