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Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

Figure 4

Mean Drug–Placebo Difference Scores as a Function of Initial Severity

Plotted values are sized according to their sample sizes (n); the green line represents the NICE clinical significance criterion. The solid blue regression line represents the trend across all 35 trials; the dashed red line represents the trend excluding the left-most observation.

Figure 4