Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray
Figure 8
Acquisition and decay models depict two possible mechanisms that account for variability in the factors secreted by activated CD8+ T lymphocytes in response to antigen recognition. Acquisition refers to independent, sequential increases in responsiveness to activation, triggered by both cellular and secreted signals. Decay accounts for maximally functional T cells immediately upon completion of priming, after which signals, or time, lead to diminished responsiveness to activation.