Asthma Severity and Prevalence: An Ongoing Interaction between Exposure, Hygiene, and Lifestyle
Figure 3
Mechanisms of T Cell Control over the Hypersensitivity Response to Cat Allergen
The response to cat allergen, Fel d 1, includes T cells that produce high levels of IL-10 that have some of the features of the T regulator one cells (Tr1). However, these cells appear to be a feature of both allergic and non-allergic responses, implying that the whole response to cat allergen is controlled. Some of the effects of cat exposure may need to occur early, but other studies suggest strongly that the different responses can change following a prolonged change in exposure late in life.