Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis

• Elizabeth P. Harausz ,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

  * E-mail: epharausz@gmail.com(EPH); annekeh@sun.ac.za (ACH)

  Affiliations Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa, Military HIV Research Program, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0001-8117-0607

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• Anthony J. Garcia-Prats,

  Roles Conceptualization, Data curation, Methodology, Supervision, Writing – review & editing

  Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

  ⨯
• Stephanie Law,

  Roles Formal analysis, Writing – review & editing

  Affiliation Montreal Chest Institute, McGill University, Montreal, Quebec, Canada

  ⨯
• H. Simon Schaaf,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

  ⨯
• Tamara Kredo,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa

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• James A. Seddon,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Centre for International Child Health, Imperial College, London, United Kingdom

  http://orcid.org/0000-0002-2296-2302

  ⨯
• Dick Menzies,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Montreal Chest Institute, McGill University, Montreal, Quebec, Canada

  ⨯
• Anna Turkova,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Imperial College Healthcare NHS Trust, Institute of Clinical Trials and Methodology, London, United Kingdom

  ⨯
• Jay Achar,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Manson Unit, Médecins Sans Frontières (MSF), London, United Kingdom

  ⨯
• Farhana Amanullah,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation The Indus Hospital, Karachi, Pakistan

  ⨯
• Pennan Barry,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation California Department of Public Health, Sacramento, California, United States of America

  ⨯
• Mercedes Becerra,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Partners In Health, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, United States of America

  ⨯
• Edward D. Chan,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Denver Veterans Affairs Medical Center, National Jewish Health, Denver, Colorado, United States of America

  ⨯
• Pei Chun Chan,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Division of Chronic Infectious Disease, Centers for Disease Control, Taipei, Taiwan

  http://orcid.org/0000-0001-7424-1868

  ⨯
• Domnica Ioana Chiotan,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Epidemiological Surveillance Department, Romanian National TB Program, Bucharest, Romania

  ⨯
• Aldo Crossa,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation New York City Department of Health and Mental Hygiene, New York, New York, United States of America

  http://orcid.org/0000-0003-3903-3320

  ⨯
• Peter C. Drobac,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Partners In Health, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0001-5190-6767

  ⨯
• Lee Fairlie,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Wits Reproductive Health & HIV Institute (WRHI), University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Dennis Falzon,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Laboratories, Diagnostics and Drug Resistance Unit, Global TB Programme, World Health Organization, Geneva, Switzerland

  http://orcid.org/0000-0001-8798-7909

  ⨯
• Jennifer Flood,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation California Department of Public Health, Sacramento, California, United States of America

  ⨯
• Medea Gegia,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Technical Support Coordination, Global TB Programme, World Health Organization, Geneva, Switzerland

  ⨯
• Robert M. Hicks,

  Roles Data curation, Investigation, Writing – review & editing

  Current address: Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States of America

  Affiliation Albert Einstein College of Medicine, Bronx, New York, United States of America

  http://orcid.org/0000-0001-8861-1225

  ⨯
• Petros Isaakidis,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Médecins Sans Frontières (MSF)/Doctors Without Borders, Mumbai, India

  http://orcid.org/0000-0002-7881-1554

  ⨯
• SM Kadri,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Disease Control, Directorate of Health Services, Kashmir, India

  http://orcid.org/0000-0002-7855-1043

  ⨯
• Beate Kampmann,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Paediatric Infection & Immunity, Centre of International Child Health, Imperial College London, London, United Kingdom, Vaccines & Immunity Theme, MRC Unit The Gambia, Banjul, The Gambia

  ⨯
• Shabir A. Madhi,

  Roles Data curation, Writing – review & editing

  Affiliation Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, and Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa

  ⨯
• Else Marais,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Clinical Microbiology and Infectious Diseases, University of the Witwatersrand and the National Health Laboratory Services, Johannesburg, South Africa

  ⨯
• Andrei Mariandyshev,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Northern State Medical University, Arkhangelsk, Russian Federation

  http://orcid.org/0000-0002-8485-5625

  ⨯
• Ana Méndez-Echevarría,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Pediatric, Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain

  ⨯
• Brittany Kathryn Moore,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Division of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• Parpieva Nargiza,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Republican Scientific Medical Center of Phtiziology and Pulmonology, Ministry of Health, Tashkent, Uzbekistan

  ⨯
• Iveta Ozere,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Riga Eastern Clinical University Hospital, Centre for Tuberculosis and Lung Diseases, Riga, Latvia

  ⨯
• Nesri Padayatchi,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation CAPRISA, MRC TB-HIV Pathogenesis Unit, Durban, South Africa

  http://orcid.org/0000-0003-2543-9071

  ⨯
• Saleem- ur-Rehman,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Director Health Services, Kashmir, India

  ⨯
• Natasha Rybak,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

  ⨯
• Begoña Santiago-Garcia,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Pediatric Infectious Diseases Unit, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain

  ⨯
• N. Sarita Shah,

  Roles Data curation, Investigation, Writing – review & editing

  Current address: Division of Global HIV and TB, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  Affiliation Albert Einstein College of Medicine, Bronx, New York, United States of America

  ⨯
• Sangeeta Sharma,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India

  ⨯
• Tae Sun Shim,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

  ⨯
• Alena Skrahina,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation The Republican Research and Practical Centre for Pulmonology and TB, Minsk, Belarus

  ⨯
• Antoni Soriano-Arandes,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Pediatric Infectious Diseases and Immunodeficiencies Unit, Unit of International Health-Tuberculosis Drassanes-Vall Hebron, Hospital Universitari Vall d'Hebron, Barcelona, Spain

  http://orcid.org/0000-0001-9613-7228

  ⨯
• Martin van den Boom,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Joint Tuberculosis, HIV & Viral Hepatitis Programme, WHO Regional Office for Europe, Copenhagen, Denmark

  http://orcid.org/0000-0002-6417-6668

  ⨯
• Marieke J. van der Werf,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Disease Programme Tuberculosis, European Centre for Disease Prevention and Control, Stockholm, Sweden

  http://orcid.org/0000-0001-8021-1358

  ⨯
• Tjip S. van der Werf,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation University Medical Center Groningen, Groningen, the Netherlands

  ⨯
• Bhanu Williams,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Northwick Park Hospital, London Northwest Healthcare NHS Trust, London, United Kingdom

  ⨯
• Elena Yablokova,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Northern State Medical University, Arkhangelsk, Russian Federation

  ⨯
• Jae-Joon Yim,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

  ⨯
• Jennifer Furin,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0002-0825-7199

  ⨯
• Anneke C. Hesseling ,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: epharausz@gmail.com(EPH); annekeh@sun.ac.za (ACH)

  Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

  ⨯
•  [ ... ],
• for the Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB

  ¶Membership of the Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB is provided in the Acknowledgments.

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