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Open Access
Peer-reviewed
Research Article
Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
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Robert Clarke ,
Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
* E-mail: Robert.Clarke@ctsu.ox.ac.uk
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
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Derrick A. Bennett ,
Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
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Sarah Parish ,
Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
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Petra Verhoef,
Affiliation Unilever Research and Development, Vlaardingen, The Netherlands
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Mariska Dötsch-Klerk,
Affiliation Unilever Research and Development, Vlaardingen, The Netherlands
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Mark Lathrop,
Affiliation Centre National de Genotypage, Evry, France
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Peng Xu,
Affiliation Centre National de Genotypage, Evry, France
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Børge G. Nordestgaard,
Affiliation Herlev Hospital Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, Denmark
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Hilma Holm,
Affiliation deCODE Inc, Rejkavik, Iceland
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Jemma C. Hopewell,
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
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Danish Saleheen,
Affiliations Department of Public Health and Primary Care, University of Cambridge, United Kingdom, Center for Non-Communicable Diseases, Karachi, Pakistan
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Toshihiro Tanaka,
Affiliation RIKEN Centre for Genomic Medicine, Yokohama, Japan
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Sonia S. Anand,
Affiliation Population Health Research Institute, Hamilton, Canada
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John C. Chambers,
Affiliation Imperial College Faculty of Medicine, University of London, London, United Kingdom
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Marcus E. Kleber,
Affiliation Luric Study Non-Profit LCC, University of Freiburg, Freiburg, Germany
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Willem H. Ouwehand,
Affiliation Department of Haematology, University of Cambridge, United Kingdom
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Yoshiji Yamada,
Affiliation Mie University Life Science Research Center, Tsu, Japan
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Clara Elbers,
Affiliation Department of Medical Genetics, University of Utrecht, Utrecht, The Netherlands
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Bas Peters,
Affiliation Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands
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Alexandre F. R. Stewart,
Affiliation Heart Institute, University of Ottawa, Ottawa, Canada
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Muredach M. Reilly,
Affiliation Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Barbara Thorand,
Affiliation Helmholtz Zentrum, Institute of Epidemiology II, German Research Center for Environmental Health, Munich, Germany
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Salim Yusuf,
Affiliation Population Health Research Institute, Hamilton, Canada
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James C. Engert,
Affiliation McGill University Health Centre, Montreal, Canada
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Themistocles L. Assimes,
Affiliation Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
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Jaspal Kooner,
Affiliation Imperial College Faculty of Medicine, University of London, London, United Kingdom
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John Danesh,
Affiliation Department of Public Health and Primary Care, University of Cambridge, United Kingdom
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Hugh Watkins,
Affiliation Department of Cardiovascular Medicine, University of Oxford, United Kingdom
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Nilesh J. Samani,
Affiliation Department of Cardiovascular Sciences, University of Leicester, United Kingdom
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Rory Collins ,
Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
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Richard Peto ,
Contributed equally to this work with: Robert Clarke, Derrick A. Bennett, Sarah Parish, Rory Collins, Richard Peto
Affiliation Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom
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for the MTHFR Studies Collaborative Group
¶Membership of the
⨯MTHFR Studies Collaborative Group is provided in the Acknowledgments. - [ view all ]
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Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias
- Robert Clarke,
- Derrick A. Bennett,
- Sarah Parish,
- Petra Verhoef,
- Mariska Dötsch-Klerk,
- Mark Lathrop,
- Peng Xu,
- Børge G. Nordestgaard,
- Hilma Holm,
- Jemma C. Hopewell
- Published: February 21, 2012
- https://doi.org/10.1371/journal.pmed.1001177