An Immune Basis for Malaria Protection by the Sickle Cell Trait

Thomas N Williams; Tabitha W Mwangi; David J Roberts; Neal D Alexander; David J Weatherall; Sammy Wambua; Moses Kortok; Robert W Snow; Kevin Marsh

doi:10.1371/journal.pmed.0020128

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Open Access

Peer-reviewed

Research Article

An Immune Basis for Malaria Protection by the Sickle Cell Trait

Thomas N Williams ,

*To whom correspondence should be addressed. E-mail: twilliams@ kilifi.mimcom.net

Affiliations Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Tabitha W Mwangi,

Affiliation Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
⨯
David J Roberts,

Affiliations Blood Research Laboratory, National Blood Service—Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Neal D Alexander,

Affiliation Medical Research Council Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
David J Weatherall,

Affiliation Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Sammy Wambua,

Affiliation Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
⨯
Moses Kortok,

Affiliation Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
⨯
Robert W Snow,

Affiliations Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Kevin Marsh

Affiliations Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯

An Immune Basis for Malaria Protection by the Sickle Cell Trait

Thomas N Williams,
Tabitha W Mwangi,
David J Roberts,
Neal D Alexander,
David J Weatherall,
Sammy Wambua,
Moses Kortok,
Robert W Snow,
Kevin Marsh

Published: May 31, 2005
https://doi.org/10.1371/journal.pmed.0020128

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27 Jul 2010
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Malaria
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Malarial parasites
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Red blood cells
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Sickle cell disease
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