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Data not in agreement with authors' interpretation

Posted by plosmedicine on 31 Mar 2009 at 00:10 GMT

Author: Idriss Bennani-Baiti
Position: Staff Scientist
Institution: Children's Cancer Research Institute
Submitted Date: June 15, 2007
Published Date: June 18, 2007
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

My comment concerns Supplementary Fig.1. In the AraC-treated cells, only four out of 12 genes (FHL2, SSX2, SSX3, and GLI) cluster to some extent with the Ews-Fli1 ShRNA-treated subset. The remaining 8 genes cluster with the untreated cells.

I am not sure how these data substantiate the authors claim, namely that "ARA-C Induces an EWS/FLI Off Signature in A673 Ewing Sarcoma Cells".

It might help to provide Affy. data from treated and non-treated cells of a larger pool of genes. The significance of data might become both meaningful and obvious to the reader.

Kindest regards,

No competing interests declared.