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Lack of intratumor heterogeneity

Posted by cmaley on 30 Oct 2009 at 18:51 GMT

genomic instability, and the heterogeneity of both tumor cells and their surrounding microenvironment

I think this is a critical issue. Since therapeutic resistance often evolves from selection on the (epi)genetic diversity within the tumor, we should be testing drugs on animal models that have high degrees of intratumor heterogeneity. I agree that the dog spontaneous tumor model is promising.

No competing interests declared.