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Posted by plosmedicine on 31 Mar 2009 at 00:15 GMT

Author: Scott Crane
Institution: UCSF Student
Submitted Date: October 06, 2007
Published Date: October 8, 2007
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

I don't know that we can totally say that most published research findings are false. However, I do agree that bias and small effective sizes can create problems when trying to get the best possible results. I also think it goes without saying that manipulating results will cause the study to be inaccurate.

No competing interests declared.