About the Authors

Jake Dunning

Contributed equally to this work with: Jake Dunning, Foday Sahr

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Foday Sahr

Contributed equally to this work with: Jake Dunning, Foday Sahr

Affiliations Military 34 Hospital, Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone, College of Medicine and Allied Health Sciences, Freetown, Sierra Leone

Amanda Rojek

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Fiona Gannon

Affiliation GOAL Global, Dun Laoghaire, Ireland

Gail Carson

Affiliations Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom, International Severe Acute Respiratory and Emerging Infection Consortium Coordinating Centre, University of Oxford, Oxford, United Kingdom

Baimba Idriss

Affiliation Military 34 Hospital, Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone

Thomas Massaquoi

Affiliation Military 34 Hospital, Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone

Regina Gandi

Affiliation Military 34 Hospital, Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone

Sebatu Joseph

Affiliation Military 34 Hospital, Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone

Hassan K. Osman

Affiliation Military 34 Hospital, Republic of Sierra Leone Armed Forces, Freetown, Sierra Leone

Timothy J. G. Brooks

Affiliation Rare and Imported Pathogens Laboratory, Public Health England, Porton Down, United Kingdom

Andrew J. H. Simpson

Affiliation Rare and Imported Pathogens Laboratory, Public Health England, Porton Down, United Kingdom

Ian Goodfellow

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Lucy Thorne

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Armando Arias

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Laura Merson

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Lyndsey Castle

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Rebecca Howell-Jones

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Raul Pardinaz-Solis

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Benjamin Hope-Gill

Affiliation Cardiff and Vale University Health Board, Cardiff, Wales, United Kingdom

Mauricio Ferri

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Jennifer Grove

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Mark Kowalski

Affiliation Tekmira Pharmaceuticals, Burnaby, British Columbia, Canada

Kasia Stepniewska

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

Trudie Lang

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

John Whitehead

Affiliation Department of Mathematics and Statistics, Lancaster University, Lancaster, United Kingdom

Piero Olliaro

Affiliations Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom, UNICEF–UNDP–World Bank–WHO Special Programme for Research and Training in Tropical Diseases, Geneva, Switzerland

Mohammed Samai

Affiliation College of Medicine and Allied Health Sciences, Freetown, Sierra Leone

Peter W. Horby

peter.horby@ndm.ox.ac.uk

Affiliation Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom

for the RAPIDE-TKM trial team

Membership of the RAPIDE-TKM trial team is provided in the Acknowledgments.

Competing Interests

We have read the journal's policy and the authors of this manuscript have the following competing interests: MK is an employee of Arbutus Biopharma (previously known as Tekmira Pharmaceuticals).

Author Contributions

Conceived and designed the experiments: PWH TL PO JW. Performed the experiments: JD FS AR FG GC BI TM RG SJ HKO TJGB AJHS IG LT AA LM LC RH-J RP-S BH-G MF JG MK KS TL JW PO MS PWH. Analyzed the data: KS JW PWH JD. Contributed reagents/materials/analysis tools: TJGB AJHS LT AA IG. Wrote the first draft of the manuscript: PWH JD FS PO. Contributed to the writing of the manuscript: TL FS GC AR FG IG JW KS. Enrolled patients: JD AR BI TM RG SJ. Agree with the manuscript’s results and conclusions: JD FS AR FG GC BI TM RG SJ HKO TJGB AJHS IG LT AA LM LC RH-J RP-S BH-G MF JG MK KS TL JW PO MS PWH. All authors have read, and confirm that they meet, ICMJE criteria for authorship.