About the Authors

Peter G. Kremsner

peter.kremsner@uni-tuebingen.de (PGK); s.krishna@sgul.ac.uk (SK)

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon

Akim A. Adegnika

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon

Aurore B. Hounkpatin

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon

Jeannot F. Zinsou

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon

Terrie E. Taylor

Affiliation Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi

Yamikani Chimalizeni

Affiliation Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi

Alice Liomba

Affiliation Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi

Maryvonne Kombila

Affiliation Department of Parasitology Mycology, Faculty of Medicine, Université des Sciences de la Santé, Libreville, Gabon

Marielle K. Bouyou-Akotet

Affiliation Department of Parasitology Mycology, Faculty of Medicine, Université des Sciences de la Santé, Libreville, Gabon

Denise P. Mawili Mboumba

Affiliation Department of Parasitology Mycology, Faculty of Medicine, Université des Sciences de la Santé, Libreville, Gabon

Tsiri Agbenyega

Affiliations Department of Physiology, University of Science and Technology, School of Medical Sciences, Kumasi, Ghana, Departments of Child Health and Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana

Daniel Ansong

Affiliations Department of Physiology, University of Science and Technology, School of Medical Sciences, Kumasi, Ghana, Departments of Child Health and Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana

Justice Sylverken

Affiliations Department of Physiology, University of Science and Technology, School of Medical Sciences, Kumasi, Ghana, Departments of Child Health and Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana

Bernhards R. Ogutu

Affiliation Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya

Godfrey A. Otieno

Affiliation Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya

Anne Wangwe

Affiliation Centre for Clinical Research, Kenya Medical Research Institute, Kisumu, Kenya

Kalifa A. Bojang

Affiliation Medical Research Council Laboratories, Fajara, The Gambia

Uduak Okomo

Affiliation Medical Research Council Laboratories, Fajara, The Gambia

Frank Sanya-Isijola

Affiliation Medical Research Council Laboratories, Fajara, The Gambia

Charles R. Newton

Affiliation Centre for Geographic Medicine Research–Coast, Kenya Medical Research Institute, Kilifi, Kenya

Patricia Njuguna

Affiliation Centre for Geographic Medicine Research–Coast, Kenya Medical Research Institute, Kilifi, Kenya

Michael Kazungu

Affiliation Centre for Geographic Medicine Research–Coast, Kenya Medical Research Institute, Kilifi, Kenya

Reinhold Kerb

Affiliations Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, Germany, Eberhard Karls Universität Tübingen, Tübingen, Germany

Mirjam Geditz

Affiliations Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, Germany, Eberhard Karls Universität Tübingen, Tübingen, Germany

Matthias Schwab

Affiliations Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie, Stuttgart, Germany, Abteilung Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany

Thirumalaisamy P. Velavan

Affiliation Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany

Christian Nguetse

Affiliation Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany

Carsten Köhler

Affiliation Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany

Saadou Issifou

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon

Stefanie Bolte

Affiliation Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany

Thomas Engleitner

Affiliation Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany

Benjamin Mordmüller

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon

Sanjeev Krishna

peter.kremsner@uni-tuebingen.de (PGK); s.krishna@sgul.ac.uk (SK)

Affiliations Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany, Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon, Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom

Competing Interests

GK, BM, CK, SB, and TE report grants from European and Developing Countries Clinical Trials Partnership and Bundesministerium für Building und Forschung Deutschland for the conduct of the study. SK reports grants from European and Developing Countries Clinical Trials Partnership for the conduct of the study, personal fees from Merck Serono and shareholder at QuantuMDx. AAA, JFZ, ABH, TET, YC, AL, MK, MKBA, DPMM, TA, DA, JS, BRO, GAO, AW, KAB, UO, FSI, CRN, PN, MK, and SI report grant from European and Developing Countries Clinical Trials Partnership for the conduct of the study. MS, MG, and RK report grants from DFG and Robert Bosch Stiftung for the conduct of the study. TPV and CN report grant from Deutsche Forschungsgemieinschaft for the conduct of the study. SK is a member of the Editorial Board of PLOS Medicine.

Author Contributions

Conceived and designed the experiments: PGK SK. Performed the experiments: AAA JFZ ABH TET YC AL MK MKBA DPMM TA DA JS BRO GAO AW KAB UO FSI CRN PN MK SI TPV CN MS MG RK. Analyzed the data: PGK SK BM TE MS MG RK TPV CN. Wrote the first draft of the manuscript: SK PGK BM. Contributed to the writing of the manuscript: AAA JFZ ABH TET YC AL MK MKBA DPMM TA DA JS BRO GAO AW KAB UO FSI CRN PN MK SI. Enrolled patients: AAA JFZ ABH TET YC AL MK MKBA DPMM TA DA JS BRO GAO AW KAB UO FSI CRN PN MK SI. Agree with the manuscript’s results and conclusions: AAA JFZ ABH TET YC AL MK MKBA DPMM TA DA JS BRO GAO AW KAB UO FSI CRN PN MK SI PGK SK BM MS MG RK TPV CN CK SB TE. Overall project managers: CK SB. All authors have read, and confirm that they meet, ICMJE criteria for authorship.