About the Authors

Rémy Boussageon

Affiliation Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

Irène Supper

Affiliation Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

Theodora Bejan-Angoulvant

Affiliations Service de Pharmacologie Clinique, Centre Hospitalier Régional et Universitaire de Tours, France, UMR 7292, CNRS, Université François Rabelais, Tours, France

Nadir Kellou

Affiliation Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

Michel Cucherat

Affiliations UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France

Jean-Pierre Boissel

Affiliations UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France

Behrouz Kassai

Affiliations UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France, Clinical Investigation Centre, INSERM CIC201, Lyon, France, Department of Clinical Pharmacology, Hospices Civils de Lyon, Lyon, France

Alain Moreau

Affiliation Department of General Medicine, Université Claude Bernard Lyon 1, Lyon, France

François Gueyffier

Affiliations UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France, Clinical Investigation Centre, INSERM CIC201, Lyon, France, Department of Clinical Pharmacology, Hospices Civils de Lyon, Lyon, France

Catherine Cornu

catherine.cornu@chu-lyon.fr

Affiliations UMR 5558, CNRS, Laboratoire de Biométrie et Biologie Évolutive, Villeurbanne, France, Université Claude Bernard Lyon 1, Lyon, France, Clinical Investigation Centre, INSERM CIC201, Lyon, France, Department of Clinical Pharmacology, Hospices Civils de Lyon, Lyon, France

Competing Interests

MC received fees for consulting from BMS and Servier. MC also received fees for speaking from AstraZeneca. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RB TBA CC FG. Performed the experiments: IS. Analyzed the data: RB CC TBA NK MC JPB BK AM. Wrote the first draft of the manuscript: RB TBA FG CC. Contributed to the writing of the manuscript: RB TBA NK AM FG CC. ICMJE criteria for authorship read and met: RB IS TBA NK MC JPB BK AM FG CC. Agree with manuscript results and conclusions: RB IS TBA NK MC JPB BK AM FG CC.