About the Authors

Robert Clarke, Derrick A. Bennett, Sarah Parish, Jemma C. Hopewell, Rory Collins, Richard Peto
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Oxford, United Kingdom

Petra Verhoef, Mariska Dötsch-Klerk
Unilever Research and Development, Vlaardingen, The Netherlands

Mark Lathrop, Peng Xu
Centre National de Genotypage, Evry, France

Børge G. Nordestgaard
Herlev Hospital Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, Denmark

Hilma Holm
deCODE Inc, Rejkavik, Iceland

Danish Saleheen, John Danesh
Department of Public Health and Primary Care, University of Cambridge, United Kingdom

Danish Saleheen
Center for Non-Communicable Diseases, Karachi, Pakistan

Toshihiro Tanaka
RIKEN Centre for Genomic Medicine, Yokohama, Japan

Sonia S. Anand, Salim Yusuf
Population Health Research Institute, Hamilton, Canada

John C. Chambers, Jaspal Kooner
Imperial College Faculty of Medicine, University of London, London, United Kingdom

Marcus E. Kleber
Luric Study Non-Profit LCC, University of Freiburg, Freiburg, Germany

Willem H. Ouwehand
Department of Haematology, University of Cambridge, United Kingdom

Yoshiji Yamada
Mie University Life Science Research Center, Tsu, Japan

Clara Elbers
Department of Medical Genetics, University of Utrecht, Utrecht, The Netherlands

Bas Peters
Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands

Alexandre F. R. Stewart
Heart Institute, University of Ottawa, Ottawa, Canada

Muredach M. Reilly
Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Barbara Thorand
Helmholtz Zentrum, Institute of Epidemiology II, German Research Center for Environmental Health, Munich, Germany

James C. Engert
McGill University Health Centre, Montreal, Canada

Themistocles L. Assimes
Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America

Hugh Watkins
Department of Cardiovascular Medicine, University of Oxford, United Kingdom

Nilesh J. Samani
Department of Cardiovascular Sciences, University of Leicester, United Kingdom

Corresponding Author

Robert.Clarke@ctsu.ox.ac.uk

Competing Interests

The Clinical Trial Service Unit has a policy of not accepting honoraria or other payments from the pharmaceutical industry, except for reimbursement of costs to participate in scientific meetings (RCl, DAB, SP, JCH, RCo, RP). PV and MDK are employees of Unilever R&D Vlaardingen, The Netherlands. Unilever makes no claims regarding B-vitamins, homocysteine, and CVD on their food products, and PV and MDK have worked on the paper due to their expertise and data from previous academic life. PV and MDK therefore do not consider this to be a competing interest but declare it for reasons of transparency. HH is an employee of deCode, a biotechnology company that produces genetic testing services. JD and RCo are on the Editorial Board of PLoS Medicine. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RCl SP RP. Performed the experiments: RCl DAB SP RP. Analyzed the data: RCl DAB SP RP. Contributed reagents/materials/analysis tools: RCl DAB SP PV MDK ML PX BGN HH JCH DS TT SSA JCC MEK WHO YY CE BP AFRS MMR BT SY JCE TLA JK JD HW NJS RCo RP. Wrote the first draft of the manuscript: RCl SP DAB RP. Contributed to the writing of the manuscript: RCl DAB SP RP. ICMJE criteria for authorship read and met: RCl DAB SP PV MDK ML PX BGN HH JCH DS TT SSA JCC MEK WHO YY CE BP AFRS MMR BT SY JCE TLA JK JD HW NJS RCo RP. Agree with manuscript results and conclusions: RCl DAB SP PV MDK ML PX BGN HH JCH DS TT SSA JCC MEK WHO YY CE BP AFRS MMR BT SY JCE TLA JK JD HW NJS RCo RP.