About the Authors

A. Sarah Walker

Contributed equally to this work with: A. Sarah Walker, David W. Eyre

asw@ctu.mrc.ac.uk

Affiliations National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Medical Research Council Clinical Trials Unit, London, United Kingdom

David W. Eyre

Contributed equally to this work with: A. Sarah Walker, David W. Eyre

Affiliation National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

David H. Wyllie

Affiliation National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

Kate E. Dingle

Affiliations National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

Rosalind M. Harding

Affiliation Department of Zoology, Oxford University, Oxford, United Kingdom

Lily O'Connor

Affiliation National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

David Griffiths

Affiliations National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

Ali Vaughan

Affiliations National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

John Finney

Affiliation National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

Mark H. Wilcox

Affiliations Department of Microbiology, The General Infirmary, Old Medical School, Leeds, United Kingdom, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom

Derrick W. Crook

Affiliations National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

Tim E. A. Peto

Affiliations National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom

Competing Interests

The institution of DWC and TEAP received per-case funding from Optimer Pharmaceuticals to support fidaxomicin trial patient expenses. DWC and TEAP also received honoraria from Optimer Pharmaceuticals for participation in additional meetings related to investigative planning for fidaxomicin. MHW has received honoraria for consultancy work, financial support to attend meetings and research funding from bioMerieux, Optimer, Novacta, Pfizer, Summit, The Medicines Company, and Viropharma. All other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TEAP ASW DCW DWE MHW RMH. Performed the experiments: DHW LOC KED DG AV JF. Analyzed the data: DWE TEAP ASW. Wrote the first draft of the manuscript: TEAP DWE ASW DWC. Contributed to the writing of the manuscript: ASW DWE DHW KED RMH LOC DG AV JF MHW DCW TEAP. ICMJE criteria for authorship read and met: ASW DWE DHW KED RMH LOC DG AV JF MHW DCW TEAP. Agree with manuscript results and conclusions: ASW DWE DHW KED RMH LOC DG AV JF MHW DCW TEAP.