About the Authors

Rose McGready

To whom correspondence should be addressed. E-mail: rose@shoklo-unit.com

Affiliations Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand , Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand , Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

Saw Oo Tan

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Elizabeth A Ashley

Affiliations Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand , Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand , Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

Mupawjay Pimanpanarak

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Jacher Viladpai-nguen

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Lucy Phaiphun

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Katja Wüstefeld

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Marion Barends

Affiliations Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand , Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Natthapon Laochan

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Lily Keereecharoen

Affiliation Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand

Niklas Lindegardh

Affiliations Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand , Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

Pratap Singhasivanon

Affiliation Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Nicholas J White

Affiliations Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand , Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

François Nosten

Affiliations Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand , Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand , Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom

Competing Interests

NJW is co-chairman of the WHO treatment guidelines committee.

Author Contributions

RM, NJW, and FN developed the study protocol. RM, SOT, EAA, MP, JV, LP, and KW oversaw the implementation of the trial, assisted with the data analysis and drafting of the manuscript. LK oversaw the field laboratory work and analysis of the malaria smear results, MB and N Laochan undertook the PCR analysis, and N Lindegardh the lumefantrine analysis. EAA, PS, NJW, and FN contributed to the monitoring of the trial and drafting of the manuscript.