About the Authors

Eric J Brunner, Mika Kivimäki, Daniel R Witte, Aroon D Hingorani, Michael G Marmot, Meena Kumari
Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Debbie A Lawlor, George Davey Smith, Nicholas J Timpson
Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

Jackie A Cooper, Steve E Humphries
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom

Michelle Miller
Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom

Gordon D. O Lowe, Ann Rumley
Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom

Juan P Casas
Non-communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom

Tina Shah
University College London Centre for Clinical Pharmacology, Division of Medicine, London, United Kingdom

Corresponding Author

e.brunner@ucl.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EJB, M. Kivimäki, DAL, MM, SEH, ADH, and M. Kumari designed the study. EJB, JAC, and MM analyzed the data. MM, GDOL, AR, TS, MGM, and M. Kumari collected data or did experiments for the study. EJB and M Kivimäki wrote the first draft of the paper. EJB, M. Kivimäki, DRW, DAL, GDS, JAC, MM, GDOL, AR, JPC, ADH, MGM, NJT, and M. Kumari contributed to writing the paper. M. Kivimäki helped in conducting the data analysis and interpretation. DRW contributed to the analysis of the data. MM supervised (scientific and administrative roles) the DNA extraction program and genotyping and was responsible for checking genotype results and in particular for verifying concordance of blind duplicates, establishing error rates, etc. GDOL supervised laboratory assays. TS selected CRP tag SNPs and conducted genotyping of these SNPs. NJT helped with analysis.