About the Authors

Eric J Brunner

To whom correspondence should be addressed. E-mail: e.brunner@ucl.ac.uk

Affiliation Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Mika Kivimäki

Affiliation Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Daniel R Witte

Affiliation Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Debbie A Lawlor

Affiliation Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

George Davey Smith

Affiliation Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

Jackie A Cooper

Affiliation Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom

Michelle Miller

Affiliation Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom

Gordon D. O Lowe

Affiliation Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom

Ann Rumley

Affiliation Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom

Juan P Casas

Affiliation Non-communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom

Tina Shah

Affiliation University College London Centre for Clinical Pharmacology, Division of Medicine, London, United Kingdom

Steve E Humphries

Affiliation Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, United Kingdom

Aroon D Hingorani

Affiliation Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Michael G Marmot

Affiliation Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Nicholas J Timpson

Affiliation Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom

Meena Kumari

Affiliation Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

EJB, M. Kivimäki, DAL, MM, SEH, ADH, and M. Kumari designed the study. EJB, JAC, and MM analyzed the data. MM, GDOL, AR, TS, MGM, and M. Kumari collected data or did experiments for the study. EJB and M Kivimäki wrote the first draft of the paper. EJB, M. Kivimäki, DRW, DAL, GDS, JAC, MM, GDOL, AR, JPC, ADH, MGM, NJT, and M. Kumari contributed to writing the paper. M. Kivimäki helped in conducting the data analysis and interpretation. DRW contributed to the analysis of the data. MM supervised (scientific and administrative roles) the DNA extraction program and genotyping and was responsible for checking genotype results and in particular for verifying concordance of blind duplicates, establishing error rates, etc. GDOL supervised laboratory assays. TS selected CRP tag SNPs and conducted genotyping of these SNPs. NJT helped with analysis.