About the Authors
- David B Savage
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Affiliation Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
- Lanmin Zhai
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Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
- Balasubramanian Ravikumar
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Affiliation School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
- Cheol Soo Choi
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Affiliation Department of Internal Medicine and Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Johanna E Snaar
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Affiliation Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom
- Amanda C McGuire
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Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
- Sung-Eun Wou
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Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
- Gemma Medina-Gomez
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Affiliation Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
- Sheene Kim
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Affiliation Department of Internal Medicine and Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Cheryl B Bock
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Affiliation Comprehensive Cancer Centre, Duke University Medical Centre, Durham, North Carolina, United States of America
- Dyann M Segvich
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Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
- Antonio Vidal-Puig
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Affiliation Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
- Nicholas J Wareham
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Affiliation Medical Research Council Epidemiology Unit, Elsie Widdowson Laboratory, Cambridge, United Kingdom
- Gerald I Shulman
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Affiliation Department of Internal Medicine and Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America
- Fredrik Karpe
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Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom
- Roy Taylor
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Affiliation School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
- Bartholomew A Pederson
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Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
- Peter J Roach
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Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
- Stephen O'Rahilly
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*To whom correspondence should be addressed. E-mail: adepaoli@iupui.edu (ADP); so104@medschl.cam.ac.uk (SOR)
Affiliation Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
- Anna A DePaoli-Roach
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*To whom correspondence should be addressed. E-mail: adepaoli@iupui.edu (ADP); so104@medschl.cam.ac.uk (SOR)
Affiliation Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States of America
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Mouse studies were designed and performed by DBS, LZ, CSC, ACG, SEW, GMG, SK, CBB, DMS, AVP, GIS, BAP, PJR and ADPR. Human studies were designed and performed by DBS, BR, JES, NJW, FK, RT and SOR. The manuscript was prepared by DBS, SOR and ADPR, and seen by all authors.