About the Authors

Soo-Huey Yap

Affiliations Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia , School of Applied Sciences and Engineering, Monash University, Churchill, Victoria, Australia

Chih-Wei Sheen

Affiliation Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Jonathan Fahey

Affiliations Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia , Department of Microbiology, Monash University, Clayton, Victoria, Australia

Mark Zanin

Affiliation Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

David Tyssen

Affiliation Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia

Viviane Dias Lima

Affiliation British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

Brian Wynhoven

Affiliation British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

Michael Kuiper

Affiliation Victorian Partnership for Advanced Computing, Carlton South, Victoria, Australia

Nicolas Sluis-Cremer

Affiliation Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

P. Richard Harrigan

Affiliation British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada

Gilda Tachedjian

To whom correspondence should be addressed. E-mail: gildat@burnet.edu.au

Affiliations Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia , Department of Microbiology, Monash University, Clayton, Victoria, Australia , Department of Medicine, Monash University, Melbourne, Victoria, Australia

Competing Interests

PRH has received honoraria, research and travel grants and served as a speaker from many pharmaceutical companies, and has served as a consultant to HIV drug resistance testing companies including Virco and Monogram Biosciences. SHY, CWS, JF, MZ, DT, VDL, BW, MK, NSC, and GT declare no competing interests.

Author Contributions

GT, PRH, NSC, and SHY designed the study. PRH and BW gathered the clinical data, and SHY, DT, JF, MZ, and CWS performed the experiments. GT, SHY, PRH, and VDL performed the statistical analyses. MK performed the structural analyses, and GT, NSC, PRH, SHY, and VDL contributed to writing the paper and analysing the data.