About the Authors
- Angela N Kuntz
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Affiliation Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
- Elisabeth Davioud-Charvet
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Affiliations Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany , Centre National de la Recherche Scientifique (CNRS), Paris, France
- Ahmed A Sayed
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Affiliation Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
- Lindsay L Califf
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Affiliation Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
- Jean Dessolin
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Affiliations Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany , Institut Européen de Chimie et Biologie, CNRS UMR 5144, Bordeaux University, Pessac Cedex, France
- Elias S. J Arnér
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Affiliation Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
- David L Williams
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*To whom correspondence should be addressed. E-mail: dlwilli@ilstu.edu
Affiliation Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America
Competing Interests
All authors have read and approved of the contents of the manuscript and none of the authors have competing financial interests. There is no significant overlap between the submitted manuscript and any other papers from the same authors under consideration or in press elsewhere.
Author Contributions
ANK, EDC, AAS, ESJA, and DLW designed the study. ANK, EDC, AAS, and LLC collected data or did experiments for the study. ANK performed the experiments involving recombinant protein expression, biochemical analysis, inhibition assays, and in vitro worm assays, and helped with in vivo experiments. AAS performed the experiments involving RNA interference, cytotoxicity assays, and helped with in vivo experiments. LLC participated in experimental drug studies to test the effects of auranofin on mice infected with S. mansoni and interpreted the results. JD synthesized some of the compounds described herein. ANK, EDC, AAS, LLC, ESJA, and DLW analyzed the data. ANK, EDC, ESJA, and DLW contributed to writing the paper. JD proofread the manuscript prior to submission.