About the Authors

Cameron P Simmons

Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Nadia L Bernasconi

Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

Affiliation Institute for Research in Biomedicine, Bellinzona, Switzerland

Amorsolo L Suguitan Jr.

Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Kimberly Mills

Contributed equally to this work with: Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan Jr., Kimberly Mills

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Jerrold M Ward

Affiliation Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Nguyen Van Vinh Chau

Affiliation Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Tran Tinh Hien

Affiliation Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Federica Sallusto

Affiliation Institute for Research in Biomedicine, Bellinzona, Switzerland

Do Quang Ha

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Jeremy Farrar

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Menno D de Jong

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam

Antonio Lanzavecchia

To whom correspondence should be addressed. E-mail: lanzavecchia@irb.unisi.ch (AL); ksubbarao@niaid.nih.gov (KS)

Affiliation Institute for Research in Biomedicine, Bellinzona, Switzerland

Kanta Subbarao

To whom correspondence should be addressed. E-mail: lanzavecchia@irb.unisi.ch (AL); ksubbarao@niaid.nih.gov (KS)

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

AL is named on a patent relating to the generation and use of human monoclonal antibodies. All other authors have no conflict of interest.

Author Contributions

CPS, NVVC, TTH, JF, and MDdJ diagnosed and recruited the patients. NB, FS and AL generated the antibodies. CS, AS, KM, MDdJ, DQH, and KS tested the antibodies in vitro and in vivo. JMW performed histopathology. CS, NB, AS, AL and KS analyzed the data and wrote the manuscript, with input from all.