Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection

Andrew Yates; Jaroslav Stark; Nigel Klein; Rustom Antia; Robin Callard

doi:10.1371/journal.pmed.0040177

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Open Access

Peer-reviewed

Research Article

Understanding the Slow Depletion of Memory CD4⁺ T Cells in HIV Infection

Andrew Yates ,

*To whom correspondence should be addressed. E-mail: ayates2@emory.edu

Affiliations Department of Biology, Emory University, Atlanta, Georgia, United States of America , Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom
⨯
Jaroslav Stark,

Affiliations Department of Mathematics, Imperial College, London, United Kingdom , Centre for Integrative Systems Biology at Imperial College, Imperial College London, United Kingdom
⨯
Nigel Klein,

Affiliation Immunobiology Unit, Institute of Child Health, London, United Kingdom
⨯
Rustom Antia,

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America
⨯
Robin Callard

Affiliations Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom , Immunobiology Unit, Institute of Child Health, London, United Kingdom
⨯

Understanding the Slow Depletion of Memory CD4⁺ T Cells in HIV Infection

Andrew Yates,
Jaroslav Stark,
Nigel Klein,
Rustom Antia,
Robin Callard

Published: May 22, 2007
https://doi.org/10.1371/journal.pmed.0040177

About the Authors

Andrew Yates

*To whom correspondence should be addressed. E-mail: ayates2@emory.edu

Affiliations Department of Biology, Emory University, Atlanta, Georgia, United States of America , Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom

Jaroslav Stark

Affiliations Department of Mathematics, Imperial College, London, United Kingdom , Centre for Integrative Systems Biology at Imperial College, Imperial College London, United Kingdom

Nigel Klein

Affiliation Immunobiology Unit, Institute of Child Health, London, United Kingdom

Rustom Antia

Affiliation Department of Biology, Emory University, Atlanta, Georgia, United States of America

Robin Callard

Affiliations Centre for Mathematics and Physics in the Life Sciences and Experimental Biology, University College London, London, United Kingdom , Immunobiology Unit, Institute of Child Health, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AY, NK, and RC designed the study. AY wrote the paper and performed the modelling. NK, RC, RA and JS contributed to writing the paper and to the development of the models.

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T cells
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Homeostasis
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HIV infections
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HIV
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Cell death
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Cell cycle and cell division
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Memory T cells
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Viral load
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