About the Authors
Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden
Steno Diabetes Center, Gentofte, Denmark
Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Department of Physiology and Pharmacology, Section Integrative Physiology, Karolinska Institute, Stockholm, Sweden
Department of Molecular Medicine and Surgical Sciences, Section Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
Diabetes Biology, Novo Nordisk A/S, Maaloev, Denmark
Program in Molecular Medicine, Helsinki University, Helsinki, Finland
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
HT is employed at Novo Nordisk A/S, Denmark and owns a minor amount of employers stock in this Company. LCG is a member of the editorial board of PLoS Medicine.
HP analysed the microarray data, performed the GEE analysis, carried out the resequencing of TXNIP, and drafted the manuscript. EC, LEJ, and MR studied the effects of glucose and insulin on TXNIP expression in the human adipocyte cell line and carried out the real-time PCR studies of TXNIP, G0S2, and BCL6. WAC, PCS, MJM, and RTL performed the glucose uptake studies in 3T3-L1 cells following genetic manipulation of Txnip expression. HS, PP, CBJ, and AV were responsible for the clinical and metabolic studies including the hyperinsulinemic euglycemic clamp studies. RS and DA were responsible for the genetic association studies. CL performed the microarray experiments. AK, MB, and JRZ performed glucose uptake studies in human skeletal muscle cells following siRNA of TXNIP. HT provided the human adipocyte cell line and was involved in planning the experiments studying the effect of glucose and insulin on TXNIP expression in these cells. LCG and VKM conceived the project, designed the study, and jointly supervised all phases of the study as well as the drafting of the manuscript.