About the Authors
- Hemang Parikh
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Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden
- Emma Carlsson
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Affiliations Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden , Steno Diabetes Center, Gentofte, Denmark
- William A Chutkow
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Affiliation Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
- Lovisa E Johansson
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Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden
- Heidi Storgaard
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Affiliation Steno Diabetes Center, Gentofte, Denmark
- Pernille Poulsen
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Affiliation Steno Diabetes Center, Gentofte, Denmark
- Richa Saxena
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Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America , Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
- Christine Ladd
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Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
- P. Christian Schulze
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Affiliation Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
- Michael J Mazzini
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Affiliation Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
- Christine Bjørn Jensen
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Affiliation Steno Diabetes Center, Gentofte, Denmark
- Anna Krook
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Affiliation Department of Physiology and Pharmacology, Section Integrative Physiology, Karolinska Institute, Stockholm, Sweden
- Marie Björnholm
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Affiliation Department of Molecular Medicine and Surgical Sciences, Section Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
- Hans Tornqvist
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Affiliation Diabetes Biology, Novo Nordisk A/S, Maaloev, Denmark
- Juleen R Zierath
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Affiliation Department of Molecular Medicine and Surgical Sciences, Section Integrative Physiology, Karolinska Institutet, Stockholm, Sweden
- Martin Ridderstråle
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Affiliation Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden
- David Altshuler
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Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America , Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
- Richard T Lee
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Affiliation Cardiovascular Division, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
- Allan Vaag
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Affiliations Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden , Steno Diabetes Center, Gentofte, Denmark
- Leif C Groop
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*To whom correspondence should be addressed. E-mail: Leif.Groop@med.lu.se (LCG); vamsi@hms.harvard.edu (VKM)
Affiliations Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmö, Malmö, Sweden , Program in Molecular Medicine, Helsinki University, Helsinki, Finland
- Vamsi K Mootha
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*To whom correspondence should be addressed. E-mail: Leif.Groop@med.lu.se (LCG); vamsi@hms.harvard.edu (VKM)
Affiliations Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America , Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America , Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Competing Interests
HT is employed at Novo Nordisk A/S, Denmark and owns a minor amount of employers stock in this Company. LCG is a member of the editorial board of PLoS Medicine.
Author Contributions
HP analysed the microarray data, performed the GEE analysis, carried out the resequencing of TXNIP, and drafted the manuscript. EC, LEJ, and MR studied the effects of glucose and insulin on TXNIP expression in the human adipocyte cell line and carried out the real-time PCR studies of TXNIP, G0S2, and BCL6. WAC, PCS, MJM, and RTL performed the glucose uptake studies in 3T3-L1 cells following genetic manipulation of Txnip expression. HS, PP, CBJ, and AV were responsible for the clinical and metabolic studies including the hyperinsulinemic euglycemic clamp studies. RS and DA were responsible for the genetic association studies. CL performed the microarray experiments. AK, MB, and JRZ performed glucose uptake studies in human skeletal muscle cells following siRNA of TXNIP. HT provided the human adipocyte cell line and was involved in planning the experiments studying the effect of glucose and insulin on TXNIP expression in these cells. LCG and VKM conceived the project, designed the study, and jointly supervised all phases of the study as well as the drafting of the manuscript.